Biest Lotion (E2 / E3)

Estradiol is the body's most potent natural estrogen and the workhorse of menopause symptom relief — flashes, sleep, mood, bone protection. Estriol is weaker, with a particular affinity for tissue maintenance: skin, vaginal mucosa, urogenital lining. Most of the estrogen of late pregnancy is estriol, which gives a sense of how the body uses it.

For some women, a pure estradiol formulation produces good systemic relief but leaves dryness or skin changes only partially addressed. Adding estriol to the formulation gives the clinician a way to fine-tune for those tissue-level concerns without using more estradiol than systemic symptoms require.

The right ratio is symptom-driven. An 80/20 blend leans on estradiol for systemic relief; a 50/50 blend gives more weight to estriol's tissue effects. Your clinician chooses based on what your assessment surfaces.

Most common: mild breast tenderness, occasional headache, light spotting in the first cycles, mild skin irritation at the application site. Typically settle within 6–12 weeks.

Less common but worth flagging: persistent breast tenderness, mood changes, irregular bleeding past the first months. Tell your clinician — sometimes a ratio or volume adjustment resolves it.

Not appropriate if: you have a personal history of breast cancer, certain estrogen-sensitive cancers, active liver disease, a history of unprovoked blood clots or stroke, unexplained vaginal bleeding, or you're pregnant. Your assessment surfaces these factors carefully.

If you have a uterus: you'll also need progesterone (or a combination preparation that already includes progesterone) to protect the uterine lining. Your clinician decides which.