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Compounded · Menopause & HRT

Estradiol Gel

Steady estrogen through the skin — a simple once-daily gel you smooth on and go.

A transdermal estradiol gel delivers estrogen through the skin, bypassing the liver's first pass. You apply a measured amount once a day to clean, dry skin — the upper arm or shoulder — and the dose is easy to titrate as your clinician fine-tunes it. For many women it's a flexible, low-fuss way to take the edge off hot flashes, night sweats, and the sleep loss that comes with them.

  • Once-daily topical gel — smooth on and go
  • Transdermal delivery bypasses first-pass liver metabolism
  • Dose is easy to titrate as your clinician adjusts
  • Compounded by a state-licensed U.S. pharmacy
  • Includes clinician oversight · direct-to-door · monthly or quarterly plans · cancel monthly anytime before your next ship date
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Your care
Clinician-ledCare
State-LicensedCompounding Pharmacies
HIPAACompliant
Available inAll 50 US states

How it works

Simple online care, built around you.

Start your assessment

3-minute screener · No commitment

1
Complete your intake
Tell us about your health history, goals, symptoms, and what's changed. This takes less than 3 minutes.
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2
Get provider review
A licensed U.S. provider reviews your information and determines whether treatment is appropriate — typically within 24 hours.
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3
Start your plan
If eligible, your plan may include a personalized compounded hormone regimen with pharmacy coordination, ongoing oversight, and direct-to-door delivery.

Our physician partner

Medical oversight by Arora Health

Your care is reviewed and overseen by board-certified, U.S.-licensed physicians at Arora Health & Aesthetics — our independent medical partner, with clinician coverage in all 50 states.

Dr. Sean Arora, Co-Founder and CEO of Arora Health & Aesthetics

Dr. Sean Arora

Arora Co-Founder & CEO

  • Board-certified physician
  • Licensed in all 50 states

Dr. Sean Arora is a board-certified physician and the founder of Arora Health & Aesthetics, bringing deep expertise in wellness, family medicine, and telehealth innovation.

He leads one of the nation's most comprehensive medical oversight and compliance networks, supporting clinics through full-spectrum medical directorship, nationwide telehealth provider coverage, and evidence-based protocol development across peptides, hormone optimization, weight loss, regenerative medicine, and aesthetic treatments.

Known for his forward-thinking approach to patient safety and scalable clinical operations, Dr. Arora partners closely with medical spas, wellness clinics, and telehealth organizations to ensure responsible, compliant, and impactful care. Licensed in all 50 states, he is dedicated to expanding access to high-quality wellness services through innovation, leadership, and patient-centered standards.

Dr. Shannon Arora, Chief Medical Officer of Arora Health & Aesthetics

Dr. Shannon Arora

Chief Medical Officer

  • Hospital-trained physician
  • Preventive & longevity medicine

Dr. Shannon Arora is a physician dedicated to making a meaningful impact on patient health through both traditional medicine and proactive wellness care.

With experience as a hospitalist, she brings a strong clinical foundation shaped by work in hospitals and nursing homes, offering a broad perspective on patient care across diverse settings. While her early career focused on acute care, Dr. Arora recognized an opportunity to create a more proactive, personalized approach within the health, wellness, and longevity space. She now focuses on optimizing patient health through advanced wellness therapies, preventative medicine, and longevity-focused care, helping patients improve energy, confidence, and overall quality of life.

As Chief Medical Officer, Dr. Arora is passionate about advancing innovation in regenerative medicine and wellness, while helping both patients and organizations achieve better outcomes through thoughtful, patient-centered care.

Why the gel

Estrogen, delivered the flexible way.

Woman in midlife at home, relaxed

Estradiol is the main estrogen your body makes — and the one that falls as you move through perimenopause and into menopause. A transdermal gel restores it steadily through the skin, and because you apply a measured amount each day, the dose is easy to titrate as your needs change.

Because the gel delivers estrogen through the skin, it skips the first pass through the liver. For some women that matters, and the daily routine makes it simple to dial the dose up or down. Your clinician will explain whether it's the right route for you.

What women on estrogen therapy most often describe: fewer and milder hot flashes, fewer night sweats, and the better sleep that follows. We don't promise a specific result — your clinician monitors how you respond and adjusts.

Using it

An easy once-daily routine. Tuned to you.

1
Starting out
Your clinician chooses a starting amount based on your symptoms and history. Each day you apply the gel to clean, dry skin — typically the upper arm or shoulder — let it dry fully, and wash your hands afterward. Using the same area at the same time each day keeps absorption consistent.
2
Finding your dose
Hormone therapy is dosed to the lowest amount that controls your symptoms. Because the gel is applied by measured amount, your clinician can adjust it gradually based on how you're feeling and tolerating it. Changes are gradual, not overnight.
3
Ongoing · Care, not just refills
Your plan includes clinician check-ins, dose adjustment, side-effect support, and a clear conversation about progesterone if you have a uterus and are on estrogen.

Side effects & safety

What to know before you start.

Woman reviewing health information at home

Most common: skin irritation or redness at the application site, breast tenderness, headache, nausea, bloating, or spotting, especially in the first weeks. These are often dose-related and tend to settle. Letting the gel dry fully and varying the application area can help with skin reactions.

Worth flagging: estrogen therapy can affect the risk of blood clots, stroke, and gallbladder disease, and — for women with a uterus who take estrogen without progesterone — the risk of endometrial cancer. Your clinician weighs these against the benefits for your individual situation.

Not appropriate if: you have a history of certain hormone-sensitive cancers, unexplained vaginal bleeding, active liver disease, or a history of blood clots or stroke, among other conditions. Tell your clinician about all medications and your full health history. If you have a uterus, estrogen is generally paired with progesterone.

Questions

Answers to
common questions.

Gel, patch, or pill — how do I choose?
You don't have to. Your clinician recommends a route based on your picture.
All deliver estradiol; they differ in routine and how the body absorbs the hormone. The gel is flexible to adjust and applied once daily; the patch is low-effort and steady; the tablet is the simplest pill routine. Your clinician will recommend a route based on your symptoms, history, and preferences — and you can revisit it if it's not the right fit.
Will I also need progesterone?
If you have a uterus, usually yes.
Estrogen on its own can thicken the uterine lining over time. For women who still have a uterus, clinicians generally add progesterone to protect it. If you've had a hysterectomy, it's often not needed. Your clinician makes this call and can prescribe both together.
How long until the gel dries — can it transfer to others?
Let it dry fully and cover the area before close contact.
Yes, estradiol gel can transfer to other people through skin-to-skin contact before it has dried, so this is worth taking seriously. Apply it to clean, dry skin, let it dry completely — usually a few minutes — then wash your hands and cover the area with clothing. Avoid letting others, especially children or partners, touch the application site until it's dry and covered. Your instructions will detail the exact wait time and precautions.
When am I charged?
Not until a clinician confirms your eligibility.
You're not charged when you submit. Your card is saved. A licensed clinician reviews your assessment, typically within 24 hours. If approved, you'll be notified by email before the first charge. If not approved, you're not charged.
Can I cancel?
Yes — with full transparency on what you've committed to.
Yes. The monthly plan can be cancelled anytime before your next ship date. The quarterly plan is a committed term — cancel future renewals after the term ends.
Can I use my FSA/HSA?
Yes — itemized receipts provided for self-submission.
Yes. HSA and FSA cards are accepted on any plan. We also provide itemized receipts in case you need to self-submit to your benefits provider.

Find out if estradiol gel fits your picture.

The symptom-led assessment is free. If you're a candidate, your clinician typically follows up within 24 hours.

Start my assessment
Start my assessment