Compounded · Needle-free GLP-1

Semaglutide Sublingual Drops

For women who'd rather skip the needle.

Daily under-the-tongue drops deliver semaglutide without the weekly injection. Same active ingredient, daily cadence, smaller individual doses. A good fit if you want to avoid needles, prefer daily routine over weekly, or are easing into GLP-1 therapy.

  • Needle-free — daily sublingual drops
  • Same GLP-1 receptor agonist as the injection
  • Compounded by a state-licensed U.S. pharmacy
  • Includes clinician oversight and ongoing support
  • Direct-to-door · cancel anytime on monthly · save more on 6 or 12-month plans
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Compounded semaglutide sublingual drops — Cypress Health

Why sublingual

A daily ritual instead of a weekly injection.

Compounded semaglutide sublingual drops for weight loss

Sublingual drops are absorbed through the tissue under the tongue, bypassing first-pass digestion. The bioavailability profile differs from injectable semaglutide, and dosing is daily rather than weekly — which some women find easier to integrate into their routine.

Sublingual delivery suits women who are needle-averse, who travel and prefer not to refrigerate medication, or who want a slightly gentler entry into GLP-1 therapy.

Whether the sublingual form is right for you depends on your medical history and goals. Your clinician will help you decide between injection and sublingual.

Dosing & what to expect

A daily routine. Adjusted as you go.

1
Daily · Starting dose
A small starting dose under the tongue, held for 60–90 seconds before swallowing. Most patients tolerate this well from day one.
2
Weeks 4+ · Dose escalation
Your clinician adjusts your daily dose based on response and tolerance. Adjustments are gradual.
3
Ongoing · Care, not just refills
Plan includes ongoing oversight, dose adjustment, side-effect support, and check-ins.

Side effects & safety

What to know before you start.

Woman reviewing health information at home

Most common: nausea, decreased appetite, mild diarrhea, constipation, fatigue. Typically dose-related.

Less common but important: pancreatitis, gallbladder issues, low blood sugar (especially with insulin/sulfonylureas).

Muscle mass during treatment: GLP-1 therapy can be associated with loss of lean mass, particularly in women in midlife. Your clinician will discuss strategies to protect muscle — typically resistance training and adequate dietary protein — as part of your care plan.

Not appropriate if: personal/family history of medullary thyroid carcinoma or MEN2; pregnant, planning pregnancy, or breastfeeding; severe GI or end-stage organ disease.

Compounded medication notice
Compounded sublingual semaglutide is dispensed by state-licensed U.S. pharmacies in FDA-regulated facilities under the patient-specific 503A exception. It is not FDA-approved as a finished product.

Clinical evidence

In STEP 1 (Wilding et al., NEJM 2021), injectable semaglutide produced an average ~14.9% body weight loss over 68 weeks at the 2.4 mg weekly dose — the largest published trial of semaglutide for chronic weight management to date.

Compounded sublingual semaglutide uses the same active ingredient delivered via a different route. Outcomes from branded injectable clinical trials cannot be directly attributed to compounded sublingual preparations, and published human data for the sublingual route specifically is more limited.

Questions

Answers to
common questions.

How is this different from Ozempic, Wegovy, or the injection?
Same active ingredient, daily under-the-tongue dosing — published evidence is more limited than for the injection.
Ozempic and Wegovy are FDA-approved branded injectable semaglutide manufactured by Novo Nordisk. Compounded sublingual semaglutide is prepared per-patient by a state-licensed U.S. pharmacy under the 503A exception — the same active ingredient delivered via daily under-the-tongue dosing instead of weekly injection. Sublingual is not FDA-approved as a finished product, and the published clinical evidence base for sublingual semaglutide in humans is more limited than for the injectable form. Your clinician will help you decide whether sublingual is appropriate, or whether the injection's stronger evidence base is the right starting point for you.
How is the sublingual format different in practice?
Daily ritual instead of weekly. Bioavailability differs from injection — your clinician sets the right dose for the route.
Drops are absorbed through the tissue under the tongue, bypassing first-pass digestion. Dosing is daily rather than weekly — some women find a daily ritual easier to integrate than a weekly injection. The bioavailability of sublingual semaglutide differs from injectable forms, so dosing schedules are not interchangeable; your clinician will set the right dose for the route. Sublingual is often chosen by women who are needle-averse, travel often, or want to ease into GLP-1 therapy with a smaller daily dose.
When am I charged?
Not until a clinician confirms your eligibility — typically within 24–48 hours.
You're not charged when you submit. Your card is saved while a licensed clinician reviews your assessment, typically within 24 to 48 hours. If approved, you'll receive an email confirmation before any charge. If not approved, you're not charged.
How will it ship — and how should I store it?
Ships via UPS or FedEx; storage instructions specific to your formulation will be included.
Once approved, the pharmacy ships within 1–2 business days via UPS or FedEx, Monday through Friday. Storage instructions specific to your formulation will be included with your shipment — most sublingual peptide preparations require refrigeration on arrival. If a shipment is lost or arrives damaged, we'll reship at no cost.
How quickly will I see results?
Most women notice appetite changes within 1–2 weeks at an effective dose.
Most women notice appetite changes within the first one to two weeks of an effective dose. The largest published outcomes data for semaglutide and weight management — including STEP 1 (NEJM 2021) — were generated using the injectable form. Outcomes from those trials cannot be directly attributed to sublingual compounded preparations, and there is less published human data for the sublingual route specifically. Your clinician will set expectations honestly based on your starting point, the dose you're on, and how your body responds.
Can I cancel? Will my insurance, HSA, or FSA cover this?
Cancel anytime on monthly. HSA/FSA usually accepted; insurance generally doesn't cover compounded.
The 1-month plan can be cancelled at any time. The 6 and 12-month plans are committed terms billed monthly — cancel future renewals after the term ends. Compounded GLP-1 medications are generally not insurance-reimbursable because they're prepared per-patient rather than as FDA-approved finished products. HSA or FSA cards are typically accepted for prescription medications; check with your benefits administrator to confirm eligibility for compounded medications under your specific plan.

Skip the needle. See if you're a candidate.

The 3-minute medical screener is free. If you're a candidate, your clinician follows up within 24 hours.

Start your assessment