Compounded · Vitality

Sermorelin Injection

Not HGH. A nudge to your own pituitary at night.

Sermorelin is a growth-hormone-releasing hormone analog — the first 29 amino acids of natural GHRH. Instead of supplying HGH directly, it asks your pituitary to release its own, on its natural overnight rhythm. For midlife women dealing with restless sleep, slow recovery, or body-composition drift despite stable habits, it can be a useful piece of a fuller protocol.

  • Subcutaneous injection at bedtime — 5 nights on, 2 nights off
  • Stimulates your own HGH — preserves the body's feedback loops
  • Compounded by a state-licensed U.S. pharmacy
  • Includes clinician oversight, dose adjustment, and side-effect support
  • Direct-to-door · cancel anytime on monthly · save more on 6 or 12-month plans
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Why sermorelin

Working with your physiology, not around it.

Woman in midlife considering her care options

Growth hormone is released in pulses, mostly during deep sleep. That release blunts noticeably from your 30s onward and is a real piece of why midlife sleep can feel less restorative even when the hours are right. Direct HGH bypasses your body's feedback loops and carries a meaningfully different risk profile. Sermorelin takes a different angle: it asks your pituitary to release its own HGH on its natural overnight schedule.

This matters for two reasons. First, your endocrine system keeps the brakes on — if HGH gets too high, your body downshifts the signal, which is much harder to do with exogenous HGH. Second, the pulsatile release pattern is preserved, which appears to be part of what makes the downstream effects work the way they do.

This is not a magic body-recomposition shortcut. Used thoughtfully alongside the basics — sleep, training, protein intake — it's a tool that may help. Used as a substitute for those things, it won't.

Nightly. Then a measured ramp.

1
Weeks 1–4 · Starting protocol
Typical starting dose is 0.2 mg subcutaneous at bedtime, 5 nights on / 2 nights off. The two off-nights are intentional — they keep the receptors responsive over time. Most women notice deeper sleep first, often within the first 2–3 weeks.
2
Weeks 5+ · Tuning
Your clinician may adjust the dose into the 0.2–0.3 mg range based on response and tolerance. Effects on recovery, body composition, and skin/hair quality build more slowly — typically over 2–3 months.
3
Ongoing · Care, not just refills
Your plan includes clinician check-ins, dose adjustment, side-effect support, and periodic IGF-1 monitoring when appropriate. Sermorelin works best in cycles — your clinician will talk through whether and when to take a break.

Side effects & safety

What to know before you start.

Woman reviewing health information at home

Most common: injection-site redness or itching, occasional flushing or warmth right after dosing, mild headache, vivid dreams in the first week or two. These are typically mild and settle as your body adjusts.

Less common but worth flagging: water retention, joint or muscle aching (transient, dose-related), and changes in fasting glucose or insulin sensitivity. Your clinician may pull baseline labs and recheck periodically.

Not appropriate if: you have an active malignancy, untreated proliferative diabetic retinopathy, severe respiratory failure, are pregnant or breastfeeding, or have certain pituitary disorders. Tell your clinician about all current medications and any history of cancer — even remote.

Compounded medication notice
Compounded sermorelin is dispensed by state-licensed U.S. pharmacies in FDA-regulated facilities under the patient-specific 503A exception. It is not FDA-approved as a finished product for this use. Your clinician will determine whether it is appropriate for your specific health profile.

Questions

Answers to
common questions.

Is this the same as HGH?
No — and the difference matters.
No. Sermorelin is a GHRH analog — it asks your pituitary to release its own growth hormone, preserving the body's natural feedback loops and pulsatile release pattern. Direct HGH bypasses those checks and carries a different risk and regulatory profile. Sermorelin is generally considered the more conservative, physiology-respecting option for adults seeking to support a flagging GH axis.
When will I notice anything?
Sleep first. Body composition is the slow part.
Many women describe deeper, more restorative sleep within the first 2–3 weeks. Recovery from training, energy, and skin/hair quality changes are slower — usually 6–12 weeks. Body-composition changes are slowest and depend heavily on your training and protein intake. If nothing has shifted by month three, your clinician will reassess.
When am I charged?
Not until a clinician confirms your eligibility.
You're not charged when you submit. Your card is saved. A licensed clinician reviews your assessment, typically within 24 hours. If approved, you'll be notified by email before the first charge. If not approved, you're not charged.
Can I cancel?
Yes — with full transparency on what you've committed to.
Yes. The 1-month plan can be cancelled anytime. The 6 and 12-month plans are committed terms billed monthly — cancel future renewals after the term ends.

See if sermorelin fits the picture.

The 3-minute vitality intake is free. If you're a candidate, your clinician follows up within 24 hours.

Start your assessment